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14-739M TLK2 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, 388-end, human TLK2. For use in Kinase Assays.

TLK2 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-739M
250 µg  Also available in 10 μg size (cat#14-739) and in bulk (cat# 14-739-K).
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number14-739M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionTLK2 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, 388-end, human TLK2.
Alternate Names
  • tousled-like kinase 2
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, 388-end, human TLK2. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]
Gene Symbol
  • TLK2
  • MGC44450
  • PKU-alpha
  • PKU-ALPHA
Protein TargetTLK2
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q86UE8 # Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
COFACTOR: Magnesium.
SIZE: 772 amino acids; 87661 Da
SUBUNIT: Heterodimerizes with TLK1. Interacts with ASF1A and ASF1B.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Widely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
SIMILARITY: SwissProt: Q86UE8 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
Molecular Weight48.8 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 6 months at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-739) and in bulk (cat# 14-739-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
14-739M 04053252411915

相关产品和应用

Alternative Packsize

产品目录编号 描述
14-739 TLK2 Protein, active, 10 µg

产品族

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种类

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases