SAB4502131
Anti-RNF138 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
E3 ubiquitin-protein ligase RNF138, NLK-associated RING finger protein, Nemo-like kinase-associated RING finger protein, RING finger protein 138
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Acerca de este artículo
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
5
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 28 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RN138(51444)
General description
Anti-RNF138 antibody detects endogenous levels of total RNF138 protein.
The RNF138 (RING (really interesting new gene) finger protein 138) gene is mapped to human chromosome 18q12.1 and is predominantly expressed in testis. It encodes an E3 ubiquitin ligase, which is a CaV2.1 (voltage gated calcium channel) binding protein. It is a 245 amino acid protein containing a RING (really interesting new gene) domain at the N-terminal, zinc fingers, and an ubiquitin interacting motif at the C-terminal.
Immunogen
The antiserum was produced against synthesized peptide derived from human RNF138.
Immunogen Range: 31-80
Immunogen Range: 31-80
Biochem/physiol Actions
Upregulation of RNF138 (RING (really interesting new gene) finger protein 138) induces polyubiquitination and increases the synthesis/degradation of CaV2.1 (voltage gated calcium channel). In response to DNA damage, RNF138 is localized to the DNA damage site mediated by zinc fingers. Deletion of RNF138 increases the sensitivity to DNA damaging agents and chromosomal instability. RNF138 is upregulated in gliomas.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels.
Fu SJ
The Journal of Neuroscience, 37(9), 2485-2503 (2017)
RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.
Yard BD
DNA Repair, 42, 82-93 (2016)
A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251.
Zhou YX
Analytical Cellular Pathology (Amsterdam), 35(3), 167-178 (2012)