Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine.

Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). We have previously shown that inactivation of the Escherichia coli cysB gene is the major cause of mecillinam resistance (Mec