121974 ω-Agatoxin IVA, Agelenopsis aperta

121974
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      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      121974-5UG
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          Plastová ampulka 5 μg
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          Description
          OverviewPotent selective high affinity blocker of P-type Ca2+ channels (Kd = 2 nM). Reported to abolish nicotine-evoked responses in cardiac vagal neurons (˜100 nM).
          Catalogue Number121974
          Brand Family Calbiochem®
          Synonymsω-Aga-IVA
          References
          ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
          Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
          Mintz, I.M., et al. 1992. Nature 355, 827.
          Turner, T.J., et al. 1992. Science 258, 310.
          Product Information
          CAS number145017-83-0
          FormWhite powder
          Hill FormulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
          Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
          Quality LevelMQ100
          Applications
          Biological Information
          Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
          Purity≥99% by HPLC
          Physicochemical Information
          Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ω-Agatoxin IVA, Agelenopsis aperta MSDS

          Title

          Safety Data Sheet (SDS) 

          References

          Přehled odkazů
          Wang, J., et al. 2001. J. Neurophysiol. 85, 164.
          Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
          Mintz, I.M., et al. 1992. Nature 355, 827.
          Turner, T.J., et al. 1992. Science 258, 310.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-May-2011 RB
          Synonymsω-Aga-IVA
          DescriptionA potent and selective blocker of the P-type voltage-dependent Ca2+ channels (Kd = 2 nM).
          FormWhite powder
          CAS number145017-83-0
          Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
          Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
          Purity≥99% by HPLC
          Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
          SolubilityH₂O (1 mg/ml) or Saline (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
          Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
          Mintz, I.M., et al. 1992. Nature 355, 827.
          Turner, T.J., et al. 1992. Science 258, 310.