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129741 α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem

α-Amanitin, Amanita sp., CAS 23109-05-9, is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: RNA polymerase 2
129741
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
23109-05-9C₃₉H₅₄N₁₀O₁₄S
Description
Overview

This product has been discontinued.



Toxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
Catalogue Number129741
Brand Family Calbiochem®
References
ReferencesBaumann, K., et al. 1994. Protein Sci. 3, 750.
Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
Tamin, A., et al. 1991. Virology 182, 393.
Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.
Product Information
CAS number23109-05-9
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₃₉H₅₄N₁₀O₁₄S
Chemical formulaC₃₉H₅₄N₁₀O₁₄S
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetRNA polymerase 2
Purity≥90% by absorbance
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBD6195000
Safety Information
R PhraseR: 26/28-33

Very toxic by inhalation and if swallowed.
Danger of cumulative effects.
S PhraseS: 36/37-28-45

Wear suitable protective clothing and gloves.

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Store in plastic following reconstitution; material adheres to glass in solution. Stock solutions are stable for up 1 week at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
129741 0

Documentation

α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem Certificates of Analysis

TitleLot Number
129741

References

Přehled odkazů
Baumann, K., et al. 1994. Protein Sci. 3, 750.
Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
Tamin, A., et al. 1991. Virology 182, 393.
Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-April-2008 RFH
DescriptionToxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
FormWhite lyophilized solid
CAS number23109-05-9
RTECSBD6195000
Chemical formulaC₃₉H₅₄N₁₀O₁₄S
Structure formulaStructure formula
Purity≥90% by absorbance
SolubilityMeOH or H₂O (10 mg/ml). Reconstitute to a concentration ≥1 mM.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Store in plastic following reconstitution; material adheres to glass in solution. Stock solutions are stable for up 1 week at 4°C.
Toxicity Highly Toxic
Merck USA index14, 373
ReferencesBaumann, K., et al. 1994. Protein Sci. 3, 750.
Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
Tamin, A., et al. 1991. Virology 182, 393.
Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.