324880 (–)-Epigallocatechin Gallate - CAS 989-51-5 - Calbiochem

324880
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₂₂H₁₈O₁₁ 989-51-5

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      324880-10MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Plastová ampulka 10 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          Description
          OverviewOne of the main polyphenolic constituents of green tea that exhibits potent antitumor, anti-inflammatory, and antioxidant properties. Arrests cell cycling at G0/G1 phase and induces apoptosis in a dose-dependent manner. Shown to inhibit PMA-induced skin thickening and to activate of protein kinase C. Also activates ornithine decarboxylase and interleukin-1α mRNA and protein expression. Acts as an inhibitor of inducible nitric oxide synthase (iNOS) gene expression and enzyme activity. Also blocks peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine. Strongly and directly inhibits telomerase in cell-free systems and in cancer cell lines. An inhibitor of Dnmt1 (IC50 = 210-470 nM). Acts as a selective and noncompetitive inhibitor of HAT activities (IC50 = 30, 50, 60 and 70 µM for p300, CBP, PCAF and TIP60) with minimal effects on HDAC, SIRT and HMTase.
          Catalogue Number324880
          Brand Family Calbiochem®
          SynonymsEGCG, (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), DNA Methyltransferase Inhibitor IV, HAT Inhibitor X, Histone Acetyltransferase Inhibitor X, p300/CBP Inhibitor VIII, PCAF Inhibitor V, DNA MTase Inhibitor IV
          References
          ReferencesChoi, K.C., et al. 2009. Cancer Res. 69, 583.
          Dell'Aicia, I., et al. 2004. EMBO reports 5, 1.
          Tachibana, H., et al. 2004. Nat. Struct. Mol. Biol. 11, 380.
          Naasami, I., et al. 1998. Biochem. Biophys. Res. Commun. 249, 391.
          Ahmad, N., et al. 1997. J. Natl. Cancer 89, 1881.
          Chan, M.M.-Y., et al. 1997. Biochem. Pharmacol. 54, 1281.
          Lin, Y.-L., and Lin, J.-K. 1997. Mol. Pharmacol. 52, 465.
          Fiala, E.S., et al. 1996. Experientia 52, 922.
          Katiyar, S.K., et al. 1995. J. Invest. Dermatol. 105, 394.
          Liao, S., et al. 1995. Cancer Lett. 96, 239.
          Yamane, T., et al. 1995. Cancer Res. 55, 2081.
          Huang, M.T., et al. 1992. Carcinogenesis 13, 947.
          Product Information
          CAS number989-51-5
          ATP CompetitiveN
          FormFaint pink solid
          Hill FormulaC₂₂H₁₈O₁₁
          Chemical formulaC₂₂H₁₈O₁₁
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPMA-induced skin thickening
          Primary Target IC<sub>50</sub>210-470 nM against Dnmt1; 30, 50, 60 and 70 µM for p300, CBP, PCAF and TIP60
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKB5200000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. DMSO stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (–)-Epigallocatechin Gallate - CAS 989-51-5 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          (–)-Epigallocatechin Gallate - CAS 989-51-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          324880

          References

          Přehled odkazů
          Choi, K.C., et al. 2009. Cancer Res. 69, 583.
          Dell'Aicia, I., et al. 2004. EMBO reports 5, 1.
          Tachibana, H., et al. 2004. Nat. Struct. Mol. Biol. 11, 380.
          Naasami, I., et al. 1998. Biochem. Biophys. Res. Commun. 249, 391.
          Ahmad, N., et al. 1997. J. Natl. Cancer 89, 1881.
          Chan, M.M.-Y., et al. 1997. Biochem. Pharmacol. 54, 1281.
          Lin, Y.-L., and Lin, J.-K. 1997. Mol. Pharmacol. 52, 465.
          Fiala, E.S., et al. 1996. Experientia 52, 922.
          Katiyar, S.K., et al. 1995. J. Invest. Dermatol. 105, 394.
          Liao, S., et al. 1995. Cancer Lett. 96, 239.
          Yamane, T., et al. 1995. Cancer Res. 55, 2081.
          Huang, M.T., et al. 1992. Carcinogenesis 13, 947.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-August-2009 JSW
          SynonymsEGCG, (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), DNA Methyltransferase Inhibitor IV, HAT Inhibitor X, Histone Acetyltransferase Inhibitor X, p300/CBP Inhibitor VIII, PCAF Inhibitor V, DNA MTase Inhibitor IV
          DescriptionOne of the main polyphenolic constituents of green tea that possesses potent antitumor, anti-inflammatory, and antioxidant properties. EGCG has been shown to inhibit PMA-induced skin thickening, activation of protein kinase C, activation of ornithine decarboxylase, and activation of interleukin-1α mRNA and protein expression. Has also been shown to inhibit inducible nitric oxide synthase (iNOS) gene expression and enzyme activity and to inhibit the peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine. Also strongly and directly inhibits telomerase. Acts as a selective and noncompetitive inhibitor of HAT activities (IC50 = 30, 50, 60 and 70 µM for p300, CBP, PCAF and TIP60) with minimal effects on HDAC, SIRT and HMTase.
          FormFaint pink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number989-51-5
          RTECSKB5200000
          Chemical formulaC₂₂H₁₈O₁₁
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO or H₂O (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. DMSO stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 3526
          ReferencesChoi, K.C., et al. 2009. Cancer Res. 69, 583.
          Dell'Aicia, I., et al. 2004. EMBO reports 5, 1.
          Tachibana, H., et al. 2004. Nat. Struct. Mol. Biol. 11, 380.
          Naasami, I., et al. 1998. Biochem. Biophys. Res. Commun. 249, 391.
          Ahmad, N., et al. 1997. J. Natl. Cancer 89, 1881.
          Chan, M.M.-Y., et al. 1997. Biochem. Pharmacol. 54, 1281.
          Lin, Y.-L., and Lin, J.-K. 1997. Mol. Pharmacol. 52, 465.
          Fiala, E.S., et al. 1996. Experientia 52, 922.
          Katiyar, S.K., et al. 1995. J. Invest. Dermatol. 105, 394.
          Liao, S., et al. 1995. Cancer Lett. 96, 239.
          Yamane, T., et al. 1995. Cancer Res. 55, 2081.
          Huang, M.T., et al. 1992. Carcinogenesis 13, 947.