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100122 A3, Hydrochloride

100122
  
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Tabulka spec. kláve

CAS #Empirical Formula
78957-85-4C₁₂H₁₃ClN₂O₂S · HCl
Description
Overview

This product has been discontinued.





A cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki = 80 µM), casein kinase II (Ki = 5.1 µM), myosin light chain kinase (Ki = 7.4 µM), protein kinase A (Ki = 4.3 µM), protein kinase C (Ki = 47 µM), and protein kinase G (Ki = 3.8 µM).
Catalogue Number100122
Brand Family Calbiochem®
SynonymsN-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl
References
ReferencesInagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.
Product Information
CAS number78957-85-4
FormOff-white solid
Hill FormulaC₁₂H₁₃ClN₂O₂S · HCl
Chemical formulaC₁₂H₁₃ClN₂O₂S · HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCK1
Primary Target K<sub>i</sub>80 µM
Secondary targetCK2 (Ki = 5.1 µM), MLCK (Ki = 7.4 µM), PKA (Ki = 4.3 µM), PKC (Ki = 47 µM), PKG (Ki = 3.8 µM)
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

A3, Hydrochloride Certificates of Analysis

TitleLot Number
100122

References

Přehled odkazů
Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsN-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl
DescriptionA cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki= 80 µM), casein kinase II (Ki= 5.1 µM), myosin light chain kinase (Ki= 7.4 µM), protein kinase A (Ki= 4.3 µM), protein kinase C (Ki= 47 µM) and protein kinase G (Ki= 3.8 µM).
FormOff-white solid
CAS number78957-85-4
Chemical formulaC₁₂H₁₃ClN₂O₂S · HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or 50% Ethanol (20 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesInagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.

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Kategorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors