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171588 Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem

171588
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₃₅H₄₆N₆O₈
Description
Overview

This product has been discontinued.



A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 > 24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).

Catalogue Number171588
Brand Family Calbiochem®
SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
References
ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₅H₄₆N₆O₈
Chemical formulaC₃₅H₄₆N₆O₈
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetReduction in Aβ deposits
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
171588

References

Přehled odkazů
Permanne, B., et al. 2002. FASEB J. 16, 860.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2008 RFH
SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
DescriptionA modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood/brain barrier and acts as a β-sheet breaker. Increases neuronal survival with a concomitant reduction in brain inflammation by inducing a dramatic reduction in Aβ deposition in a transgenic mouse model of Alzheimer's disease. Displays greater stability against proteolytic degradation (t½ > 24 h in human plasma and cerebrospinal fluid; ~37 min in blood).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₅H₄₆N₆O₈
Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.