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100109 AACOCF₃ - CAS 149301-79-1 - Calbiochem

100109
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
149301-79-1C₂₁H₃₁F₃O
Description
OverviewA cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2 (cPLA2; IC50 = ~20 µM). Specific inhibition of cPLA2 activity by AACOCF3 partially inhibits TNF-induced apoptosis without inhibition of caspase activity. Causes a significant diminution in thromboxane B2 production in thrombin-stimulated platelets. Also inhibits platelet aggregation in response to collagen and arachidonic acid.
Catalogue Number100109
Brand Family Calbiochem®
SynonymsArachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II
References
ReferencesAlmeida T., et al. 1999. Brain Res. 826, 104.
Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
Street, I.P., et al. 1993. Biochemistry 32, 5935.
Product Information
CAS number149301-79-1
ATP CompetitiveN
FormClear yellow oil
Hill FormulaC₂₁H₃₁F₃O
Chemical formulaC₂₁H₃₁F₃O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetcPLA2
Primary Target IC<sub>50</sub>20 µM inhibiting cytosolic (85 kDa) phospholipase A2 (cPLA2)
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 11

Highly flammable.
S PhraseS: 16-7

Keep away from sources of ignition - No Smoking.
Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for 1-2 months at -20°C or -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AACOCF₃ - CAS 149301-79-1 - Calbiochem Certificates of Analysis

TitleLot Number
100109

References

Přehled odkazů
Almeida T., et al. 1999. Brain Res. 826, 104.
Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
Street, I.P., et al. 1993. Biochemistry 32, 5935.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-August-2011 JSW
SynonymsArachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II
DescriptionA cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of human cytosolic (85 kDa) phospholipase A2 (PLA2). Causes a significant reduction in thromboxane B2 production in thrombin-stimulated platelets.
FormClear yellow oil
Intert gas (Yes/No) Packaged under inert gas
CAS number149301-79-1
Chemical formulaC₂₁H₃₁F₃O
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityDMSO (10 mg/ml) or Ethanol (50 mg/ml)
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for 1-2 months at -20°C or -70°C.
Toxicity Flammable
ReferencesAlmeida T., et al. 1999. Brain Res. 826, 104.
Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
Street, I.P., et al. 1993. Biochemistry 32, 5935.