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121761 AG 957

121761
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information
Description
Overview

This product has been discontinued.

We apologize for the inconvenience, but we do not currently have an alternative product. Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210bcr-abl phosphorylation in viable K562 cells at concentrations and durations of exposure that also inhibit cell proliferation. Reported to alter the physical state of p210bcr-abl and the association of p210bcr-abl with Shc and Grb2 in K562 cells.
Catalogue Number121761
Brand Family Calbiochem®
Synonyms4-Amino-N-(2,5-dihydroxybenzyl)methyl benzoate, NSC 654705
References
ReferencesBhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.
Product Information
FormOff-white solid
Hill FormulaC₁₅H₁₅NO₄
Chemical formulaC₁₅H₁₅NO₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetp210bcr-abl
Primary Target K<sub>i</sub>750 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AG 957 Certificates of Analysis

TitleLot Number
121761

References

Přehled odkazů
Bhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2008 RFH
Synonyms4-Amino-N-(2,5-dihydroxybenzyl)methyl benzoate, NSC 654705
DescriptionA potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210brc-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210brc-abl phosphorylation in living K562 cells at a concentration and duration of exposure that also inhibits cell proliferation. It has recently been shown that AG 957 can alter the physical state of p210bcr-abl and the association of p210brc-abl with Shc and Grb2 in K562 cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₅NO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.