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114825 Adapalene - CAS 106685-40-9 - Calbiochem

114825
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₈H₂₈O₃

Ceny a dostupnost

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114825-25MG
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      25 mg
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      Vyžádat nacenění
      Description
      OverviewA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
      Catalogue Number114825
      Brand Family Calbiochem®
      SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
      References
      ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
      Product Information
      CAS number106685-40-9
      FormWhite solid
      Hill FormulaC₂₈H₂₈O₃
      Chemical formulaC₂₈H₂₈O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adapalene - CAS 106685-40-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Adapalene - CAS 106685-40-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      114825

      References

      Přehled odkazů
      Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-September-2010 RFH
      SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
      DescriptionA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number106685-40-9
      Chemical formulaC₂₈H₂₈O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (12 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.

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      Kategorie

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Vitamins, Coenzymes and Cofactors