115500 Adenophostin A, Hexasodium Salt - Calbiochem

115500
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical Formula
      C₁₆H₂₀N₅O₁₈P₃ · 6Na

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      115500-50UG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          50 μg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          Description
          OverviewOne of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
          Catalogue Number115500
          Brand Family Calbiochem®
          References
          ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationAdenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.
          Biological Information
          Primary TargetType 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
          Primary Target IC<sub>50</sub>EC50 = 10.9 nM against InsP3R
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenophostin A, Hexasodium Salt - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Adenophostin A, Hexasodium Salt - Calbiochem Certificates of Analysis

          TitleLot Number
          115500

          References

          Přehled odkazů
          Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          DescriptionA glyconucleotide originally isolated from the culture broth of Penicillium brevicompactum. Adenophostin A is the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R). Exhibits about 50-100 fold greater affinity for the InsP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R. Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to degradation by the enzymes that metabolize (1,4,5)InsP3.
          FormWhite solid
          Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

          Související produkty a aplikace

          Accessories (Primary)

          Katalogové číslo Popis  
          101114 Vypouštěcí systém pro rozpouštědla Zobrazit ceny a dostupnost
          106710 Čerpací systém pro nerezové sudy a nádrže Zobrazit ceny a dostupnost
          108803 Klíč pro otvírání sudů Zobrazit ceny a dostupnost
          901756 Dip tube Zobrazit ceny a dostupnost
          902698 Tlakové bezpečnostní zařízení 0,5 bar Zobrazit ceny a dostupnost
          963533 Bezpečnostní nosič Zobrazit ceny a dostupnost
          964205 Redukční ventil, 0,2 bar s 2 hadicovými spojkami 6 x 8 mm a integrovaná bezpečnostní pojistka proti nadměrnému tlaku 0,5 bar Zobrazit ceny a dostupnost

          Accessories (Secondary)

          Katalogové číslo Popis  
          100801 Souprava štítků dle GHS Zobrazit ceny a dostupnost
          107070 Antistatické zařízení Zobrazit ceny a dostupnost
          108801 Klíč pro otvírání lahví Zobrazit ceny a dostupnost
          119171 Čerpací systém pro rozpouštědla Zobrazit ceny a dostupnost

          Kategorie

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators