Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

116815 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem

A cell-permeable cAMP analog that binds cAMP-receptor proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA

Primary Target: cAMP-receptor proteins
116815
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
71774-13-5C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH

Products

Katalogové čísloBalení ks/bal.
116815-10UMOL Plastová ampulka 10 umol
Description
OverviewA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.
Note: 10 µmol = 4.47 mg.
Catalogue Number116815
Brand Family Calbiochem®
SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
References
ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
Product Information
CAS number71774-13-5
ATP CompetitiveN
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormCrystalline solid
Hill FormulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetcAMP-receptor proteins
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Katalogové číslo GTIN
116815-10UMOL4055977208252

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem Certificates of Analysis

TitleLot Number
116815

References

Přehled odkazů
Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-October-2007 JSW
SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
DescriptionA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λmax = 258 nm; εmax = 15,000 M-1cm-1 (pH 7..0).
FormCrystalline solid
CAS number71774-13-5
Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (20 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.