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124005 Akt Inhibitor - Calbiochem

124005
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₃₀H₅₈O₁₀

Ceny a dostupnost

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124005-1MG
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      Plastová ampulka 1 mg
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      Vyžádat nacenění
      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
      Catalogue Number124005
      Brand Family Calbiochem®
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      References
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.
      Product Information
      CAS number290812-38-3
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₃₀H₅₈O₁₀
      Chemical formulaC₃₀H₅₈O₁₀
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationThis Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>5.0 µM for Akt (PKB)
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Akt Inhibitor - Calbiochem Certificates of Analysis

      TitleLot Number
      124005

      References

      Přehled odkazů
      Hu, Y., et al. 2000 J. Med. Chem. 43, 3045.

      Brochure

      Title
      Akt
      Biologics 31.1
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-June-2011 JSW
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number290812-38-3
      Chemical formulaC₃₀H₅₈O₁₀
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (200 mg/ml). Use anhydrous DMSO for reconstitution.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.