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128135 Aloisine, RP106

128135
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
496864-15-4C₁₇H₁₉N₃O
Description
Overview

This product has been discontinued.





A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3 (IC50 = 700 nM, 1.5 µM, and 920 nM, respectively).
Catalogue Number128135
Brand Family Calbiochem®
SynonymsRP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
References
ReferencesMettey, Y., et al. 2003. J. Med. Chem. 46, 222.
Product Information
CAS number496864-15-4
ATP CompetitiveY
FormCream-colored solid
Hill FormulaC₁₇H₁₉N₃O
Chemical formulaC₁₇H₁₉N₃O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCdkl1, Cdkl5, GSK-3
Primary Target IC<sub>50</sub>700 nM, 1.5 µM, 920 µM against Cdkl1, Cdkl5, GSK-3, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aloisine, RP106 MSDS

Title

Safety Data Sheet (SDS) 

Aloisine, RP106 Certificates of Analysis

TitleLot Number
128135

References

Přehled odkazů
Mettey, Y., et al. 2003. J. Med. Chem. 46, 222.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 RFH
SynonymsRP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
DescriptionA cell-permeable, pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 700 nM), Cdk5/p25 (IC50 = 1.5 µM), and GSK-3 (IC50 = 920 nM).
FormCream-colored solid
Intert gas (Yes/No) Packaged under inert gas
CAS number496864-15-4
Chemical formulaC₁₇H₁₉N₃O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or MeOH (200 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMettey, Y., et al. 2003. J. Med. Chem. 46, 222.