176901 Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem

176901
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical Formula
      C₈₁H₁₅₀N₄₂O₁₇

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      176901-1MG
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          Plastová ampulka 1 mg
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          Vyžádat nacenění
          Description
          OverviewA cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
          Catalogue Number176901
          Brand Family Calbiochem®
          SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          References
          ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₈₁H₁₅₀N₄₂O₁₇
          Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetanthrax LF metalloprotease
          Primary Target K<sub>i</sub>1 nM against Anthrax lethal factor (LF) metalloprotease
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem Certificates of Analysis

          TitleLot Number
          176901

          References

          Přehled odkazů
          Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-April-2008 RFH
          SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          DescriptionA cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
          Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml), 5% Acetic Acid (5 mg/ml), or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.