239784 Anti-Cyclophilin D (42-54) Rabbit pAb

239784
  
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      Description
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      This product has been discontinued.





      Recognizes a ~15 kDa protein in rat liver and heart and a ~37 kDa protein in rat brain extract.
      Catalogue Number239784
      Brand Family Calbiochem®
      Application Data
      Detection of rat cyclophilin D by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Cyclophilin D (42-54) Rabbit pAb (Cat. No. 239784) (1 µg/ml). Detection: chemiluminescence.

      Detection of rat cyclophilin D by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Cyclophilin D (42-54) Rabbit pAb (Cat. No. 239784) (1 µg/ml). Detection: chemiluminescence.
      References
      ReferencesHalestrap, A.P., et al. 2000. Biochem. Soc. Trans. 28, 170.
      Andreeva, L., et al. 1999. Int. J. Exp. Pathol. 80, 305.
      Product Information
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:1000)
      Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide [SGNPLVYLDVDAN(C)] corresponding to amino acids 42-54 of mature human cyclophilin D (also called cyclophilin F)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cyclophilin D (42-54) Rabbit pAb Certificates of Analysis

      TitleLot Number
      239784

      References

      Přehled odkazů
      Halestrap, A.P., et al. 2000. Biochem. Soc. Trans. 28, 170.
      Andreeva, L., et al. 1999. Int. J. Exp. Pathol. 80, 305.

      Citations

      Název
    • Sheng Gu, et al. (2004) Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging. Molecular and Cellular Proteomics 3, 998-1003.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2007 RFH
      ApplicationImmunoblotting (1:1000)
      Application Data
      Detection of rat cyclophilin D by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Cyclophilin D (42-54) Rabbit pAb (Cat. No. 239784) (1 µg/ml). Detection: chemiluminescence.

      Detection of rat cyclophilin D by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Cyclophilin D (42-54) Rabbit pAb (Cat. No. 239784) (1 µg/ml). Detection: chemiluminescence.
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes a ~15 kDa protein in rat liver and heart and a ~37 kDa protein in rat brain extract.
      BackgroundCyclophilin D is an immunophilin, a family of soluble cytosolic receptors capable of binding to one of two major immuno-suppressant agents, cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind CsA are called cyclophilins. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immuno-suppressant compounds. Immunophilins accelerate folding of proteins in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins. Cyclophilin D is located in the intermembrane space of the mitochondria where it is an integral member of the permeability transition pore complex that includes the voltage dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT).
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide [SGNPLVYLDVDAN(C)] corresponding to amino acids 42-54 of mature human cyclophilin D (also called cyclophilin F)
      IsotypeIgG
      Speciescanine, hamster, human, mouse, rat
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesHalestrap, A.P., et al. 2000. Biochem. Soc. Trans. 28, 170.
      Andreeva, L., et al. 1999. Int. J. Exp. Pathol. 80, 305.
      Citation
    • Sheng Gu, et al. (2004) Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging. Molecular and Cellular Proteomics 3, 998-1003.