343002 Anti-FLIP (447-464) Rabbit pAb

343002
  
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~55 kDa long form of human FLIP. Does not cross-react with the short form of human FLIP.
      Catalogue Number343002
      Brand Family Calbiochem®
      SynonymsAnti-CASHα Anti-CASH, Anti-Casper, Anti-CLARP, Anti-FLAME-1, Anti-I-FLICE
      Application Data
      Detection of human FLIP by immunoblotting. Sample: Whole cell lysate from K562 cells at dilutions 1 µg/ml (lane A) and 2 µg/ml (lane B). Primary antibody: Anti-FLIP (447-464) Rabbit pAb (Cat. No. 343002) (2 µg/ml). Detection: chemiluminescence.
      References
      ReferencesGoltsev, Y.V., et al. 1997. J. Biol. Chem. 272, 19641.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Inohara, N., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 10717.
      Irmler, M., et al. 1997. Nature 388, 190.
      Shu, H.B., et al. 1997. Immunity 6, 751.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Srinivasula, S.M., et al. 1997. J. Biol. Chem. 272, 18542.
      Thome, M., et al. 1997. Nature 386, 517.
      Product Information
      FormLiquid
      FormulationIn PBS.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1:500-1:1000, colorimetric)
      Application CommentsDoes not recognize the (FLIPS) short form of FLIP. Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogena synthetic peptide [(C)NGYMYDWNSRVSAKEKYY] corresponding to amino acids 447-464 of human FLIP, conjugated to carrier protein
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-FLIP (447-464) Rabbit pAb Certificates of Analysis

      TitleLot Number
      343002

      References

      Přehled odkazů
      Goltsev, Y.V., et al. 1997. J. Biol. Chem. 272, 19641.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Inohara, N., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 10717.
      Irmler, M., et al. 1997. Nature 388, 190.
      Shu, H.B., et al. 1997. Immunity 6, 751.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Srinivasula, S.M., et al. 1997. J. Biol. Chem. 272, 18542.
      Thome, M., et al. 1997. Nature 386, 517.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-August-2007 RFH
      SynonymsAnti-CASHα Anti-CASH, Anti-Casper, Anti-CLARP, Anti-FLAME-1, Anti-I-FLICE
      ApplicationImmunoblotting (1:500-1:1000, colorimetric)
      Application Data
      Detection of human FLIP by immunoblotting. Sample: Whole cell lysate from K562 cells at dilutions 1 µg/ml (lane A) and 2 µg/ml (lane B). Primary antibody: Anti-FLIP (447-464) Rabbit pAb (Cat. No. 343002) (2 µg/ml). Detection: chemiluminescence.
      DescriptionPurified rabbit polyclonal antibody. Recognizes the ~55 kDa long form of human FLIP (FLIPL).
      BackgroundFLIP (FLICE-inhibitory protein) interacts with the Fas-associating protein FADD and with caspases 8 and 10 (FLICE), and potently inhibits apoptosis induced by death receptors CD95, TNFR1, DR3, and TRAIL-R. FLIP contains two death effector domains and a caspase-like domain, but lacks the catalytic active site and substrate binding pocket found in caspases. FLIP is expressed as both a long (FLIPL) and short (FLIPS) form.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide [(C)NGYMYDWNSRVSAKEKYY] corresponding to amino acids 447-464 of human FLIP, conjugated to carrier protein
      IsotypeIgG
      Specieshuman
      FormLiquid
      FormulationIn PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsDoes not recognize the (FLIPS) short form of FLIP. Variables associated with assay conditions will dictate the proper working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesGoltsev, Y.V., et al. 1997. J. Biol. Chem. 272, 19641.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Inohara, N., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 10717.
      Irmler, M., et al. 1997. Nature 388, 190.
      Shu, H.B., et al. 1997. Immunity 6, 751.
      Hu, S., et al. 1997. J. Biol. Chem. 272, 17255.
      Srinivasula, S.M., et al. 1997. J. Biol. Chem. 272, 18542.
      Thome, M., et al. 1997. Nature 386, 517.