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178495 Apoptosis Activator IV, Apoptolidin

178495
  
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Přehled

Replacement Information
Description
Overview

This product has been discontinued.





A cell-permeable macrolide antibiotic that induces apoptosis in E1A-transformed cells (IC50 = 11 ng/ml) with high selectivity. Although the apoptotic activity of apoptolidin correlates with its F0F1-ATPase inhibition (IC50 = 700 nM in yeast), the basis of the cancer selectivity is still not fully understood. Apoptolidin quickly isomerizes to and co-exists with Isoapoptolidin (Cat. No. 371959) in equilibrium (k1 = 0.0656 h-1 and Keq = 0.616 in Dulbecco's PBS at 37°C).
Catalogue Number178495
Brand Family Calbiochem®
SynonymsApoptolidin, Nocardiopsis sp.
References
ReferencesDaniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
Kim, J.W., et al. 1997. J. Antibiot. 50, 628.
Product Information
CAS number194874-06-1
FormWhite lyophilized solid
Hill FormulaC₅₈H₉₆O₂₁
Chemical formulaC₅₈H₉₆O₂₁
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Apoptosis Activator IV, Apoptolidin Certificates of Analysis

TitleLot Number
178495

References

Přehled odkazů
Daniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
Kim, J.W., et al. 1997. J. Antibiot. 50, 628.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
SynonymsApoptolidin, Nocardiopsis sp.
DescriptionA cell-permeable macrolide antibiotic that induces apoptosis in E1A-transformed cells (IC50 = 11 ng/ml) with high selectivity. Although the apoptotic activity of apoptolidin correlates with its F0F1-ATPase inhibition (IC50 = 700 nM in yeast), the basis of the cancer selectivity is still not fully understood. Apoptolidin quickly isomerizes to and co-exists with Isoapoptolidin (Cat. No. 371959) in equilibrium (k1 = 0.0656 h-1 and Keq = 0.616 in Dulbecco's PBS at 37°C).
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
CAS number194874-06-1
Chemical formulaC₅₈H₉₆O₂₁
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesDaniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
Kim, J.W., et al. 1997. J. Antibiot. 50, 628.