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182300 Aristolochic Acid

182300
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
313-67-7C₁₇H₁₁NO₇
Description
Overview

This product has been discontinued.





A 1:1 mixture of aristolochic acids I and II. Phenanthrenecarboxylic acid derivative found in Aristolochiaceae that has been reported to inhibit phospholipase A2 (PLA2) from various snake venoms as well as human platelet and synovial fluid PLA2. Inhibits ionophore-stimulated PLA2 activity (IC50 = 40 µM) in human neutrophils. Exhibits greater inhibitory activity towards group II PLA2 than group I PLA2.
Catalogue Number182300
Brand Family Calbiochem®
References
ReferencesLindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
Product Information
CAS number313-67-7
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₇H₁₁NO₇
Chemical formulaC₁₇H₁₁NO₇
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetionophore-stimulated PLA 2 activity
Primary Target IC<sub>50</sub>40 µM inhibiting ionophore-stimulated PLA2 activity in human neutrophils
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCF3325000
Safety Information
R PhraseR: 23/24/25-40

Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Aristolochic Acid MSDS

Title

Safety Data Sheet (SDS) 

Aristolochic Acid Certificates of Analysis

TitleLot Number
182300

References

Přehled odkazů
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-October-2009 JSW
DescriptionA 1:1 mixture of aristolochic acids I and II. Phenanthrenecarboxylic acid derivative occurring in Aristolochiaceae that has been reported to inhibit phospholipase A2 (PLA2) from various snake venoms as well as human platelet and synovial fluid PLA2. Also inhibits ionophore-stimulated PLA2 activity (IC50 = 40 µM) and Ca2+-dependent arachidonic acid released in human neutrophils. Exhibits greater inhibitory activity towards group II PLA2 versus group I PLA2.
FormYellow solid
CAS number313-67-7
RTECSCF3325000
Chemical formulaC₁₇H₁₁NO₇
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 786
ReferencesLindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.