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203696 BPIQ-I

203696
  
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₁₆H₁₂BrN₅ 174709-30-9
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM).
      Catalogue Number203696
      Brand Family Calbiochem®
      Synonyms8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline
      References
      ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
      Product Information
      CAS number174709-30-9
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₆H₁₂BrN₅
      Chemical formulaC₁₆H₁₂BrN₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>25 pM against tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BPIQ-I Certificates of Analysis

      TitleLot Number
      203696

      References

      Přehled odkazů
      Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline
      DescriptionA cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number174709-30-9
      Chemical formulaC₁₆H₁₂BrN₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.