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197223 Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II

197223
  
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical Formula
      C₁₆H₁₁F₂N₃OS₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
      Catalogue Number197223
      Brand Family Calbiochem®
      Synonyms5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
      References
      ReferencesRadi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.
      Product Information
      CAS number607702-99-8
      FormWhite solid
      Hill FormulaC₁₆H₁₁F₂N₃OS₂
      Chemical formulaC₁₆H₁₁F₂N₃OS₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      197223

      References

      Přehled odkazů
      Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      Synonyms5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
      DescriptionA cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number607702-99-8
      Chemical formulaC₁₆H₁₁F₂N₃OS₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Toxicity Standard Handling
      ReferencesRadi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.