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197223 Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem

197223
  
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Tabulka spec. kláve

CAS #Empirical Formula
607702-99-8C₁₆H₁₁F₂N₃OS₂
Description
Overview

This product has been discontinued.



A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.

Catalogue Number197223
Brand Family Calbiochem®
Synonyms5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
References
ReferencesRadi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.
Product Information
CAS number607702-99-8
FormWhite solid
Hill FormulaC₁₆H₁₁F₂N₃OS₂
Chemical formulaC₁₆H₁₁F₂N₃OS₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem Certificates of Analysis

TitleLot Number
197223

References

Přehled odkazů
Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2011 RFH
Synonyms5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
DescriptionA cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number607702-99-8
Chemical formulaC₁₆H₁₁F₂N₃OS₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Toxicity Standard Handling
ReferencesRadi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.