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203882 CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem

203882
  
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Tabulka spec. kláve

CAS #Empirical Formula
1084893-56-0C₂₄H₂₉N₇O
Description
OverviewA cell-permeable (R)-DRF053 (Cat. No. 219494) analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC50 = 0.15, 0.080, 0.060, 0.12, 0.11, and 0.61 µM against CDK1/B, CDK2/A, CDK2/E, CDK5/p25, CDK9/T, and CK1δ/ε, respectively). Although (S)-CR8 displays in general similar kinase inhibitory profile as its (R)-enantiomer (Cat. No. 203881), it does exhibit more enhanced and reduced activity against, respectively, Dyrk1A (IC50 = 0.9 µM) and GSK-3α/β (IC50 ≥ 30 µM). Both (R)- and (S)-CR8 are much more effective than (R)-Roscovitine (Cat. Nos. 550360 and 550364) in apoptosis induction in cell cultures.
Catalogue Number203882
Brand Family Calbiochem®
Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8
References
ReferencesBettayeb, K., et al. 2008. Oncogene 27, 5797.
Product Information
CAS number1084893-56-0
FormOff-white solid
Hill FormulaC₂₄H₂₉N₇O
Chemical formulaC₂₄H₂₉N₇O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem Certificates of Analysis

TitleLot Number
203882

References

Přehled odkazů
Bettayeb, K., et al. 2008. Oncogene 27, 5797.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8
DescriptionA cell-permeable (R)-DRF053 (Cat. No. 219494) analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC50 = 0.15, 0.080, 0.060, 0.12, 0.11, and 0.61 µM against CDK1/B, CDK2/A, CDK2/E, CDK5/p25, CDK9/T, and CK1δ/ε, respectively). Although (S)-CR8 displays in general similar kinase inhibitory profile as its (R)-enantiomer (Cat. No. 203881), it does exhibit more enhanced and reduced activity against, respectively, Dyrk1A (IC50 = 0.9 µM) and GSK-3α/β (IC50 ≥30 µM). Both (R)- & (S)-CR8 are much more effective than (R)-Roscovitine (Cat. Nos. 550360 & 550364) in apoptosis induction in cell cultures.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1084893-56-0
Chemical formulaC₂₄H₂₉N₇O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (35 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBettayeb, K., et al. 2008. Oncogene 27, 5797.