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400006 Caspase-1/Caspase-4 Substrate II, Fluorogenic

400006
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information
Description
OverviewA fluorogenic substrate for caspase-1 (kcat/Km = 2.41 x 105 M-1s-1) and caspase-4. Exhibits ~2 fold higher affinity towards caspase-1 than for caspase-4.
Catalogue Number400006
Brand Family Calbiochem®
SynonymsAc-WVAD-AMC
References
ReferencesLee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.
Product Information
FormLyophilized
Hill FormulaC₃₅H₄₀N₆O₉
Chemical formulaC₃₅H₄₀N₆O₉
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Emission max.
Excitation max.
Peptide SequenceAc-Trp-Val-Ala-Asp-AMC
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
400006 0

Documentation

References

Přehled odkazů
Lee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
SynonymsAc-WVAD-AMC
DescriptionA fluorogenic substrate for caspase-1 (kcat/Km = 241 mM-1s-1) and caspase-4. Exhibits ~2-fold higher affinity for caspase-1 than caspase-4 and displays ~4-fold greater sensitivity than Ac-YVAD-AMC (Cat. No. 400020) for measuring caspase-1 activity. Excitation max: ~360-380 nm; emission max: ~430-460 nm.
FormLyophilized
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₅H₄₀N₆O₉
Peptide SequenceAc-Trp-Val-Ala-Asp-AMC
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLee, D., et al. 1999. Bioorg. Med. Chem. Lett. 9, 1667. Rano, T.A., et al. 1997. Chem. Biol. 4, 149.