264155 Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

264155
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₃₀H₄₁FN₄O₁₂ 210344-95-9

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      264155-1MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Plastová ampulka 1 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          264155-250UG
          Zjišťuji dostupnost...
          Omezená dostupnostOmezená dostupnost
          Na skladě 
          Přerušeno
          Dostupné omezené množství
          Dostupnost bude potvrzena
            Remaining : Will advise
              Remaining : Will advise
              Bude poskytnuto
              Kontaktujte Zákaznický servis
              Contact Customer Service

              Plastová ampulka 250 μg
              Zjišťuji cenu...
              Cenu nelze zjistit
              Minimum Quantity needs to be mulitiple of
              S dokončenou objednávkou Další informace
              Ušetřili jste ()
               
              Vyžádat nacenění
              Description
              OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
              Catalogue Number264155
              Brand Family Calbiochem®
              SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
              References
              ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Product Information
              CAS number210344-95-9
              ATP CompetitiveN
              FormWhite to slightly brown solid
              Hill FormulaC₃₀H₄₁FN₄O₁₂
              Chemical formulaC₃₀H₄₁FN₄O₁₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
              Biological Information
              Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
              Purity≥90% by TLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem MSDS

              Title

              Safety Data Sheet (SDS) 

              Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              264155

              References

              Přehled odkazů
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.

              Brochure

              Title
              Caspases and other Apoptosis Related Tools Brochure

              Citations

              Název
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision31-March-2011 RFH
              SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
              DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
              FormWhite to slightly brown solid
              CAS number210344-95-9
              Chemical formulaC₃₀H₄₁FN₄O₁₂
              Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
              Structure formulaStructure formula
              Purity≥90% by TLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Citation
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.