218769 Caspase-8, Human, Recombinant, E. coli

218769
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      218769-3000U
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      Dostupné omezené množství
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          Plastová ampulka 3000 u
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          Description
          OverviewRecombinant, human caspase-8 fused at the N- and C- termini to a His•Tag® sequence and expressed in E. coli as a single polypeptide. Subsequently undergoes spontaneous autoprocessing to yield the active enzyme. Suitable for the study of enzyme regulation and kinetics, target substrate cleavage, and inhibitor screening. MW: 11000 and 18000.
          M.W. 11,000 and 18,000 (heterodimer).
          Catalogue Number218769
          Brand Family Calbiochem®
          SynonymsFLICE, MACH, Mch5
          References
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Boldin, M.P., et al. 1996. Cell 85, 803.
          Fernandes-Alnemri, T., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 7464.
          Muzio, M., et al. 1996. Cell 85, 817.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that will cleave 1.0 pmol substrate Ac-IETD-<i>p</i>NA (<a href ="/Products/ProductDisplay.asp→catNO=368057">Cat. No. 368057</a>) per min at 30°C, pH 7.4.
          FormLiquid
          FormulationIn 100 mM NaCl, 50 mM HEPES, 10 mM DTT, 1 mM EDTA, 10% glycerol, 0.5% CHAPS, pH 7.4.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-8, Human, Recombinant, E. coli MSDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-8, Human, Recombinant, E. coli Certificates of Analysis

          TitleLot Number
          218769

          References

          Přehled odkazů
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Boldin, M.P., et al. 1996. Cell 85, 803.
          Fernandes-Alnemri, T., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 7464.
          Muzio, M., et al. 1996. Cell 85, 817.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Název
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Thomas Simmen, et al. (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. European Molecular Biology Organization Journal 24, 717-729.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-September-2007 RFH
          SynonymsFLICE, MACH, Mch5
          DescriptionRecombinant, human caspase-8 fused at the N- and C- termini to a His•Tag® sequence and expressed in E. coli as a single polypeptide. Subsequently undergoes spontaneous autoprocessing to yield the active enzyme. Suitable for the study of enzyme regulation and kinetics, target substrate cleavage, and inhibitor screening. MW: 11000 and 18000.
          FormLiquid
          FormulationIn 100 mM NaCl, 50 mM HEPES, 10 mM DTT, 1 mM EDTA, 10% glycerol, 0.5% CHAPS, pH 7.4.
          Purity≥90% by SDS-PAGE
          Unit definitionOne unit is defined as the amount of enzyme that will cleave 1.0 pmol substrate Ac-IETD-pNA (Cat. No. 368057) per min at 30°C, pH 7.4.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°).
          Toxicity Standard Handling
          ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Boldin, M.P., et al. 1996. Cell 85, 803.
          Fernandes-Alnemri, T., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 7464.
          Muzio, M., et al. 1996. Cell 85, 817.
          Citation
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Thomas Simmen, et al. (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. European Molecular Biology Organization Journal 24, 717-729.