218761 Caspase-9 Inhibitor I - Calbiochem

218761
  
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical Formula
      C₃₂H₄₃FN₆O₁₀
      Description
      Overview

      This product has been discontinued.



      A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218841) in DMSO is also available.

      Catalogue Number218761
      Brand Family Calbiochem®
      SynonymsZ-LE(OMe)HD(OMe)-FMK
      References
      ReferencesFadeel, B., et al. 1999. Leukemia 13, 719.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Product Information
      ATP CompetitiveN
      FormWhite to light brown solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₂H₄₃FN₆O₁₀
      Chemical formulaC₃₂H₄₃FN₆O₁₀
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationCaspase-9 Inhibitor I, CAS 210345-04-3, is a potent, cell-permeable, and irreversible inhibitor of caspase-9.
      Biological Information
      Primary Targetcaspase-4, caspase-5, caspase-9
      Puritysingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-9 Inhibitor I - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-9 Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      218761

      References

      Přehled odkazů
      Fadeel, B., et al. 1999. Leukemia 13, 719.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Název
    • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
    • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      SynonymsZ-LE(OMe)HD(OMe)-FMK
      DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-9.
      FormWhite to light brown solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₃₂H₄₃FN₆O₁₀
      Peptide SequenceZ-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
      Puritysingle spot by TLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFadeel, B., et al. 1999. Leukemia 13, 719.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Citation
    • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
    • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.