219362 Cathepsin B, Human Liver

219362
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      219362-50UG
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          Plastová ampulka 50 μg
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          Description
          OverviewNative cathepsin B from human liver, purified by affinity chromatography and HPLC. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities. Cathepsin B is shown to facilitate tumor invasion by dissolving extracellular barriers.
          Catalogue Number219362
          Brand Family Calbiochem®
          References
          ReferencesHirai, K., et al. 1999. Hum. Pathol. 30, 680.
          Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
          Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
          Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
          Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.
          Product Information
          CAS number9047-22-7
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-β-naphthylamide per min at 40°C, using 100 mM Na<sup>+</sup>/K<sup>+</sup> pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
          EC number3.4.22.1
          FormLiquid
          FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥10 units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cathepsin B, Human Liver MSDS

          Title

          Safety Data Sheet (SDS) 

          Cathepsin B, Human Liver Certificates of Analysis

          TitleLot Number
          219362

          References

          Přehled odkazů
          Hirai, K., et al. 1999. Hum. Pathol. 30, 680.
          Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
          Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
          Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
          Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-May-2010 JSW
          DescriptionNative cathepsin B from human liver, purified by affinity chromatography and HPLC. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities.
          FormLiquid
          FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
          SourcePrepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9047-22-7
          EC number3.4.22.1
          Purity≥95% by SDS-PAGE
          Specific activity≥10 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-β-naphthylamide per min at 40°C, using 100 mM Na+/K+ pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          Merck USA index14, 1905
          ReferencesHirai, K., et al. 1999. Hum. Pathol. 30, 680.
          Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
          Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
          Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
          Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.