230751 Chromeceptin

230751
  
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₁₉H₁₆F₃N₃O 331859-86-0
      Description
      Overview

      This product has been discontinued.





      A cell-permeable benzochromene compound that blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at ≤ 20 ng/µl) and selectively suppresses IGF2- (insulin-like growth factor 2) dependent growth of HepG2 carcinoma cells (IC50 = 29 nM). Shown to bind to MFP-2 (multifunctional protein-2) and activate STAT6-mediated gene expression, such as IGFBP-1 and SOCS-3, in HepG2 cells.
      Catalogue Number230751
      Brand Family Calbiochem®
      Synonyms2-Amino-3-cyano-4-(3-trifluoromethylphenyl)-7-(N,N-dimethylamino)-chrom-2-ene, 94G6
      References
      ReferencesChoi, Y., et al. 2006. Chem. Biol. 13, 241.
      Choi, Y., et al. 2003. J. Biol. Chem. 278, 7320.
      Product Information
      CAS number331859-86-0
      FormBrown solid
      Hill FormulaC₁₉H₁₆F₃N₃O
      Chemical formulaC₁₉H₁₆F₃N₃O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Chromeceptin Certificates of Analysis

      TitleLot Number
      230751

      References

      Přehled odkazů
      Choi, Y., et al. 2006. Chem. Biol. 13, 241.
      Choi, Y., et al. 2003. J. Biol. Chem. 278, 7320.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2008 RFH
      Synonyms2-Amino-3-cyano-4-(3-trifluoromethylphenyl)-7-(N,N-dimethylamino)-chrom-2-ene, 94G6
      DescriptionA cell-permeable benzochromene compound that blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at ≤ 20 ng/µl) and selectively suppresses IGF2- (insulin-like growth factor 2) dependent growth of HepG2 carcinoma cells (IC50 = 29 nM). Shown to bind to MFP-2 (multifunctional protein-2) and activate STAT6-mediated gene expression, such as IGFBP-1 and SOCS-3, in HepG2 cells.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331859-86-0
      Chemical formulaC₁₉H₁₆F₃N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChoi, Y., et al. 2006. Chem. Biol. 13, 241.
      Choi, Y., et al. 2003. J. Biol. Chem. 278, 7320.