260905 DNase γ Inhibitor, 6-DTAF

260905
  
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      Přehled

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      A cell-permeable triazinyl-aminofluorescein compound that acts as a potent and selective inhibitor of DNase γ, human (IC50 = 3.2 µM) with minimal effects on DNase I, bovine (Cat. No. 260913; IC50 > 300 µM). Shown to prevent DNase γ-catalyzed apoptotic DNA fragmentation in HeLa-γ cells induced by Staurosporine (Cat. No. 569397) and in rat splenocytes exposed to γ-ray irradiation. Does neither affect PARP cleavage nor CAD (caspase activated DNase)-mediated DNA fragmentation.
      Catalogue Number260905
      Brand Family Calbiochem®
      Synonyms4-(4,6-Dichloro-[1,3,5]-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid, 6-(4,6-Dichlorotriazinyl)aminofluorescein, DR396
      References
      ReferencesOkamoto, M., et al. 2005. Biochem. Biophys. Res. Commun. 327, 76. Sunaga, S., et al. 2004. Biochem. Biophys. Res. Commun. 325, 1292.
      Product Information
      CAS number82169-58-2
      FormYellow solid
      Hill FormulaC₂₃H₁₂Cl₂N₄O₅
      Chemical formulaC₂₃H₁₂Cl₂N₄O₅
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetDnase γ, human
      Primary Target IC<sub>50</sub>3.2 µM
      Secondary targetDnase-1,bovine = 300 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      DNase γ Inhibitor, 6-DTAF Certificates of Analysis

      TitleLot Number
      260905

      References

      Přehled odkazů
      Okamoto, M., et al. 2005. Biochem. Biophys. Res. Commun. 327, 76. Sunaga, S., et al. 2004. Biochem. Biophys. Res. Commun. 325, 1292.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms4-(4,6-Dichloro-[1,3,5]-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid, 6-(4,6-Dichlorotriazinyl)aminofluorescein, DR396
      DescriptionA cell-permeable, potent, and selective inhibitor of human DNase γ (IC50 = 3.2 µM) with minimal effects on DNase I, Bovine (Cat. No. 260913; IC50 >300 µM). Shown to prevent DNase γ-catalyzed apoptotic DNA fragmentation in rat splenocytes exposed to γ-ray irradiation and in HeLa cells transfected with DNAse γ and induced by Staurosporine (Cat. No. 569397). Does not affect PARP cleavage or CAD (caspase activated DNase)-mediated DNA fragmentation.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number82169-58-2
      Chemical formulaC₂₃H₁₂Cl₂N₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (15 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesOkamoto, M., et al. 2005. Biochem. Biophys. Res. Commun. 327, 76. Sunaga, S., et al. 2004. Biochem. Biophys. Res. Commun. 325, 1292.