371209 Dkk-2, Mouse, Recombinant

371209
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Purity
      ≥95% by SDS-PAGE

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      371209-10UG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Skleněná láhev 10 μg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          Description
          OverviewRecombinant, mouse Dickkopf related protein 2 (Dkk-2) consisting of amino acids 26-259 and expressed in S. frugiperda 21 cells with a C-terminal His•Tag® sequence. Dkk proteins are expressed in mesenchymal tissues and control epithelial transformations.
          Catalogue Number371209
          Brand Family Calbiochem®
          References
          ReferencesMorvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
          Mukhopadhyay, M. et al. 2006. Development 133, 2149.
          Niehrs, C. 2006. Oncogene 25, 7469.
          Li, X. et al. 2005. Nat. Genet. 37, 945.
          Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
          Mao, B. and C. Niehrs 2003. Gene 302, 179.
          Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
          Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
          Mao, B. et al. 2002. Nature 417, 664.
          Mao, B. et al. 2001. Nature 411, 321.
          Wu, W. et al. 2000. Current Biol. 10,1611.
          Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
          Krupnik, V.E. et al. 1999. Gene 238, 301.
          Product Information
          FormSolid
          FormulationLyophilized from 0.2 µm filtered PBS, BSA.
          Quality LevelMQ100
          Applications
          Biological Information
          Biological activityInhibition assay:
          Inhibits WNT-3a-induced alkaline phosphatase production in MC3T3-E1 mouse osteoblastic cells in the presence of BMP-2.

          Competetive Binding Assay:
          Inhibits 50% binding of biotinylated rhDkk-1 (200 ng/ml) to immobilized rmKremen (4 µg/ml) at a concentration of 5-15 µg/ml.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1.0 EU per/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Dkk-2, Mouse, Recombinant MSDS

          Title

          Safety Data Sheet (SDS) 

          Dkk-2, Mouse, Recombinant Certificates of Analysis

          TitleLot Number
          371209

          References

          Přehled odkazů
          Morvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
          Mukhopadhyay, M. et al. 2006. Development 133, 2149.
          Niehrs, C. 2006. Oncogene 25, 7469.
          Li, X. et al. 2005. Nat. Genet. 37, 945.
          Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
          Mao, B. and C. Niehrs 2003. Gene 302, 179.
          Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
          Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
          Mao, B. et al. 2002. Nature 417, 664.
          Mao, B. et al. 2001. Nature 411, 321.
          Wu, W. et al. 2000. Current Biol. 10,1611.
          Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
          Krupnik, V.E. et al. 1999. Gene 238, 301.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2011 RFH
          DescriptionRecombinant, mouse Dickkopf related protein 2 (Dkk-2) consisting of amino acids 26-259 and expressed in S. frugiperda 21 cells with a C-terminal His•Tag® sequence. Dkk proteins are expressed in mesenchymal tissues and control epithelial transformations.
          FormSolid
          FormulationLyophilized from 0.2 µm filtered PBS, BSA.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: <1.0 EU per/µg protein
          Biological activityInhibition assay:
          Inhibits WNT-3a-induced alkaline phosphatase production in MC3T3-E1 mouse osteoblastic cells in the presence of BMP-2.

          Competetive Binding Assay:
          Inhibits 50% binding of biotinylated rhDkk-1 (200 ng/ml) to immobilized rmKremen (4 µg/ml) at a concentration of 5-15 µg/ml.
          SolubilityReconstitute to 100 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMorvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
          Mukhopadhyay, M. et al. 2006. Development 133, 2149.
          Niehrs, C. 2006. Oncogene 25, 7469.
          Li, X. et al. 2005. Nat. Genet. 37, 945.
          Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
          Mao, B. and C. Niehrs 2003. Gene 302, 179.
          Brott, B. and S.Y. Sokol 2002. Mol. Cell. Biol. 22, 6100.
          Li, L. et al. 2002. J. Biol. Chem. 277, 5977.
          Mao, B. et al. 2002. Nature 417, 664.
          Mao, B. et al. 2001. Nature 411, 321.
          Wu, W. et al. 2000. Current Biol. 10,1611.
          Monaghan, A.P. et al. 1999. Mech. Dev. 87, 45.
          Krupnik, V.E. et al. 1999. Gene 238, 301.