344150 FPT Inhibitor I - Calbiochem

344150
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical Formula
      C₁₉H₂₉NO₆P · 3Na

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      344150-1MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Plastová ampulka 1 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          Description
          OverviewPotent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
          Catalogue Number344150
          Brand Family Calbiochem®
          Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
          References
          ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₉H₂₉NO₆P · 3Na
          Chemical formulaC₁₉H₂₉NO₆P · 3Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetFarnesyltransferase (Ftase)
          Primary Target IC<sub>50</sub>83 nM against Ftase
          Purity≥85% by NMR
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FPT Inhibitor I - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          FPT Inhibitor I - Calbiochem Certificates of Analysis

          TitleLot Number
          344150

          References

          Přehled odkazů
          Manne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-December-2008 JSW
          Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
          DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₂₉NO₆P · 3Na
          Structure formulaStructure formula
          Purity≥85% by NMR
          SolubilityH₂O (≥10 mg/ml)
          Storage ≤ -70°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
          Toxicity Standard Handling
          ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.

          Související produkty a aplikace

          Related Products

          Katalogové číslo Popis  
          344152 FPT Inhibitor II - Calbiochem Zobrazit ceny a dostupnost
          344154 FPT Inhibitor III - Calbiochem Zobrazit ceny a dostupnost

          Kategorie

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors