344273 Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

344273
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₂₉H₄₈N₂O₇ · 2HCl 115116-37-5

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      344273-10MG
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          Plastová ampulka 10 mg
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          344273-5MG
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              Plastová ampulka 5 mg
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              Description
              OverviewChemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.
              Catalogue Number344273
              Brand Family Calbiochem®
              SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
              References
              ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
              Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
              Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
              Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
              Product Information
              CAS number115116-37-5
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₂₉H₄₈N₂O₇ · 2HCl
              Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              ApplicationForskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, CAS 115116-37-5, is a chemically-modified forskolin for greater stability and water solubility.
              Biological Information
              Primary TargetAdenylate cyclase
              Primary Target IC<sub>50</sub>EC50 = 13 µM in activating adenylate cyclase
              Purity≥92% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 21

              Harmful in contact with skin.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +15°C to +30°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem MSDS

              Title

              Safety Data Sheet (SDS) 

              Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              344273

              References

              Přehled odkazů
              Yang, C.M., et al. 1999. Cell Signal. 11, 697.
              Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
              Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
              Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.

              Brochure

              Title
              Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision31-March-2011 RFH
              SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
              DescriptionA chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC50 = 13 µM).
              FormWhite solid
              CAS number115116-37-5
              Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
              Structure formulaStructure formula
              Purity≥92% by HPLC
              SolubilityMethanol or H₂O (12 mg/ml)
              Storage +15°C to +30°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
              Toxicity Harmful
              ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
              Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
              Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
              Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.