344270 Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

344270
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₂₂H₃₄O₇ 66575-29-9

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      344270-10MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Plastová ampulka 10 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          344270-25MG
          Zjišťuji dostupnost...
          Omezená dostupnostOmezená dostupnost
          Na skladě 
          Přerušeno
          Dostupné omezené množství
          Dostupnost bude potvrzena
            Remaining : Will advise
              Remaining : Will advise
              Bude poskytnuto
              Kontaktujte Zákaznický servis
              Contact Customer Service

              Plastová ampulka 25 mg
              Zjišťuji cenu...
              Cenu nelze zjistit
              Minimum Quantity needs to be mulitiple of
              S dokončenou objednávkou Další informace
              Ušetřili jste ()
               
              Vyžádat nacenění
              344270-50MG
              Zjišťuji dostupnost...
              Omezená dostupnostOmezená dostupnost
              Na skladě 
              Přerušeno
              Dostupné omezené množství
              Dostupnost bude potvrzena
                Remaining : Will advise
                  Remaining : Will advise
                  Bude poskytnuto
                  Kontaktujte Zákaznický servis
                  Contact Customer Service

                  Plastová ampulka 50 mg
                  Zjišťuji cenu...
                  Cenu nelze zjistit
                  Minimum Quantity needs to be mulitiple of
                  S dokončenou objednávkou Další informace
                  Ušetřili jste ()
                   
                  Vyžádat nacenění
                  Description
                  OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
                  Catalogue Number344270
                  Brand Family Calbiochem®
                  Synonyms7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin
                  References
                  ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
                  Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
                  Galli, C., et al. 1995. J. Neurosci. 15, 1172.
                  Li, X., et al. 1995. Am. J. Physiol. 269, C986.
                  Lomo, J., et al. 1995. J. Immunol. 154, 1634.
                  Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
                  Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
                  Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
                  Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
                  Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
                  Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
                  Product Information
                  CAS number66575-29-9
                  ATP CompetitiveN
                  FormWhite to off-white crystalline solid
                  Hill FormulaC₂₂H₃₄O₇
                  Chemical formulaC₂₂H₃₄O₇
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  Biological Information
                  Primary TargetAdenylate cyclase
                  Primary Target IC<sub>50</sub>25 µM inhibiting MAP kinase in rat renal mesangial cells; EC50 = 4 µM for activation of adenylate cyclase
                  Purity≥99% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSQL6150000
                  Safety Information
                  R PhraseR: 21

                  Harmful in contact with skin.
                  S PhraseS: 36

                  Wear suitable protective clothing.
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage +15°C to +30°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem MSDS

                  Title

                  Safety Data Sheet (SDS) 

                  Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  344270

                  References

                  Přehled odkazů
                  D'Orazio, J.A., et al. 2006. Nature 443, 340.
                  Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
                  Galli, C., et al. 1995. J. Neurosci. 15, 1172.
                  Li, X., et al. 1995. Am. J. Physiol. 269, C986.
                  Lomo, J., et al. 1995. J. Immunol. 154, 1634.
                  Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
                  Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
                  Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
                  Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
                  Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
                  Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.

                  Brochure

                  Title
                  Activators and Inhibitors of Adenylate Cyclase Technical Bulletin

                  Citations

                  Název
                • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.
                • Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,.
                • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision20-November-2008 JSW
                  Synonyms7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin
                  DescriptionA cardioactive diterpene isolated from the Indian plant Coleus forskolii. At low doses, acts as a positive inotropic agent in dogs, cats, spontaneously hypertensive and normal rats, and isolated guinea pig heart. At higher doses, acts as a hypotensive and vasodilatory agent due to its action as a smooth muscle relaxant. No major side effects are observed at effective doses. Rapid and reversible activator of adenylate cyclase (EC50 = 4 µM) in membranes and intact cells. Does not affect the activity of guanylate cyclase or cyclic nucleotide phophodiesterases. The exact mechanism of forskolin's positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability, which results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B-lymphocytes.
                  FormWhite to off-white crystalline solid
                  CAS number66575-29-9
                  RTECSQL6150000
                  Chemical formulaC₂₂H₃₄O₇
                  Structure formulaStructure formula
                  Purity≥99% by HPLC
                  SolubilityDMSO (5 mg/ml). Ethanol is reported to inhibit forskolin-mediated activation of adenylate cyclase. DMSO is the recommended solvent; at ≤5% DMSO final concentration, little inhibition of the adenylate cyclase activation will occur.
                  Storage +15°C to +30°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.
                  Toxicity Harmful
                  Merck USA index14, 2476
                  ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
                  Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
                  Galli, C., et al. 1995. J. Neurosci. 15, 1172.
                  Li, X., et al. 1995. Am. J. Physiol. 269, C986.
                  Lomo, J., et al. 1995. J. Immunol. 154, 1634.
                  Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
                  Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
                  Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
                  Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
                  Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
                  Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
                  Citation
                • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.
                • Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,.
                • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.