344350 Foxm1b Inhibitor, Cell-permeable

344350
  
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      Přehled

      Replacement Information
      Description
      OverviewA cell-permeable p19ARF26-44 tumor suppressor peptide that contains an N-terminal membrane transducing nine D-Arginine sequence and inhibits the transcriptional activity of Foxm1b (Forkhead Box m1b). Shown to significantly diminish growth of Foxm1b-transfected U2OS cells, while exhibiting no cytotoxic or apoptotic effects towards non-transfected cells at the same peptide concentration (12 µM).
      Catalogue Number344350
      Brand Family Calbiochem®
      SynonymsRRRRRRRRR-KFVRSRRPRTASCALAFVN, (D-Arg)₉-p19ARF26-44
      References
      ReferencesKalinichenko, V.V., et al. 2004. Genes Dev. 18, 830.
      Product Information
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₉H₂₆₇N₆₉O₃₃S
      Chemical formulaC₁₄₉H₂₆₇N₆₉O₃₃S
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Lys-Phe-Val-Arg-Ser-Arg-Arg-Pro-Arg-Thr-Ala-Ser-Cys-Ala-Leu-Ala-Phe-Val-Asn-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in degassed H₂O, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Unstable in buffer.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Foxm1b Inhibitor, Cell-permeable Certificates of Analysis

      TitleLot Number
      344350

      References

      Přehled odkazů
      Kalinichenko, V.V., et al. 2004. Genes Dev. 18, 830.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      SynonymsRRRRRRRRR-KFVRSRRPRTASCALAFVN, (D-Arg)₉-p19ARF26-44
      DescriptionA cell-permeable p19ARF26-44 tumor suppressor peptide that contains an N-terminal, membrane transducing nine D-Arginine sequence and inhibits the transcriptional activity of Forkhead Box m1b (Foxm1b). Shown to significantly diminish growth of Foxm1b-transfected U2OS cells, while exhibiting no cytotoxic or apoptotic effects in non-transfected cells at the same peptide concentration (12 µM).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄₉H₂₆₇N₆₉O₃₃S
      Peptide SequenceH-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Lys-Phe-Val-Arg-Ser-Arg-Arg-Pro-Arg-Thr-Ala-Ser-Cys-Ala-Leu-Ala-Phe-Val-Asn-OH
      Purity≥95% by HPLC
      SolubilityDegassed H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in degassed H₂O, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Unstable in buffer.
      Toxicity Standard Handling
      ReferencesKalinichenko, V.V., et al. 2004. Genes Dev. 18, 830.