361554 GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

361554
Cenu nelze zjistit
Minimum Quantity needs to be mulitiple of
S dokončenou objednávkou Další informace
Ušetřili jste ()
 
Vyžádat nacenění
Omezená dostupnostOmezená dostupnost
Na skladě 
Přerušeno
Dostupné omezené množství
Dostupnost bude potvrzena
    Remaining : Will advise
      Remaining : Will advise
      Bude poskytnuto
      Kontaktujte Zákaznický servis
      Contact Customer Service
      Zobrazit ceny a dostupnost

      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₁₈H₁₄N₄O₂ 601514-19-6

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      361554-1MG
      Zjišťuji dostupnost...
      Omezená dostupnostOmezená dostupnost
      Na skladě 
      Přerušeno
      Dostupné omezené množství
      Dostupnost bude potvrzena
        Remaining : Will advise
          Remaining : Will advise
          Bude poskytnuto
          Kontaktujte Zákaznický servis
          Contact Customer Service

          Plastová ampulka 1 mg
          Zjišťuji cenu...
          Cenu nelze zjistit
          Minimum Quantity needs to be mulitiple of
          S dokončenou objednávkou Další informace
          Ušetřili jste ()
           
          Vyžádat nacenění
          361554-5MG
          Zjišťuji dostupnost...
          Omezená dostupnostOmezená dostupnost
          Na skladě 
          Přerušeno
          Dostupné omezené množství
          Dostupnost bude potvrzena
            Remaining : Will advise
              Remaining : Will advise
              Bude poskytnuto
              Kontaktujte Zákaznický servis
              Contact Customer Service

              Plastová ampulka 5 mg
              Zjišťuji cenu...
              Cenu nelze zjistit
              Minimum Quantity needs to be mulitiple of
              S dokončenou objednávkou Další informace
              Ušetřili jste ()
               
              Vyžádat nacenění
              Description
              OverviewA cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
              Catalogue Number361554
              Brand Family Calbiochem®
              SynonymsNeurogenesis Inducer, TWS119
              References
              ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
              Product Information
              CAS number601514-19-6
              ATP CompetitiveN
              FormBeige solid
              Hill FormulaC₁₈H₁₄N₄O₂
              Chemical formulaC₁₈H₁₄N₄O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetGSK-3β
              Primary Target IC<sub>50</sub>30 nM; Kd = 126 nM against GSK-3β
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem MSDS

              Title

              Safety Data Sheet (SDS) 

              GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem Certificates of Analysis

              TitleLot Number
              361554

              References

              Přehled odkazů
              Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision12-April-2011 RFH
              SynonymsNeurogenesis Inducer, TWS119
              DescriptionA cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
              FormBeige solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number601514-19-6
              Chemical formulaC₁₈H₁₄N₄O₂
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (200 mg/ml) or Methanol (2 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.