218706 InSolution™ Casein Kinase II Inhibitor, DMAT

218706
  
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      Přehled

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We are offering Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.

      Catalogue Number218706
      Brand Family Calbiochem®
      References
      ReferencesPagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (5 mg/1.05 ml) solution of Casein Kinase II Inhibitor, DMAT (Cat. No. 218699), in DMSO
      Hill FormulaC₉H₇Br₄N₃
      Chemical formulaC₉H₇Br₄N₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCK2
      Primary Target IC<sub>50</sub>140 nM
      Secondary targetCK2 Ki = 40 nM, CK1 (IC₅₀ > 200 µM)
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Casein Kinase II Inhibitor, DMAT MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Casein Kinase II Inhibitor, DMAT Certificates of Analysis

      TitleLot Number
      218706

      References

      Přehled odkazů
      Pagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-June-2008 RFH
      DescriptionA cell-permeable, potent, high affinity, and ATP-competitive inhibitor of CK2 (IC50 = 150 nM for rat liver CK2; Ki = 40 nM). Displays ~1,300 fold greater selectivity over CK1 (IC50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No. 218697) in cell studies. Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Also shown to induce apoptosis in Jurkat T cells at 2.5 µM.
      FormLiquid
      FormulationA 10 mM (5 mg/1.05 ml) solution of Casein Kinase II Inhibitor, DMAT (Cat. No. 218699), in DMSO
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      Chemical formulaC₉H₇Br₄N₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesPagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.