Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

110110 N-Acetyl-S-farnesyl-L-cysteine

110110
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information
Description
Overview

This product has been discontinued.





Exhibits high affinity for S-farnesylcysteine methyl transferase (Km = 20 µM) thereby inhibiting the COOH-terminal methylation of protein in cell-free extracts and in whole cells. An inhibitor of β2-integrin-induced actin polymerization (IC50 = 5.5 µM). Known to block the fMLP-induced release of superoxides in human neutrophils (IC50 = 15 µM). Also inhibits carboxyl methylation of p21 platelet Rap1 and the γ-subunit of transducin.
Catalogue Number110110
Brand Family Calbiochem®
SynonymsAFC
References
ReferencesMolony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.
Product Information
CAS number135304-07-3
FormClear oil
Hill FormulaC₂₀H₃₃NO₃S
Chemical formulaC₂₀H₃₃NO₃S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetβ2-integrin-induced actin polymerization
Primary Target IC<sub>50</sub>5.5 µM
Secondary targetKnown to block the fMLP-induced release of superoxides in human neutrophils (IC₅₀ = 15 µM)
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

N-Acetyl-S-farnesyl-L-cysteine Certificates of Analysis

TitleLot Number
110110

References

Přehled odkazů
Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-March-2011 JSW
SynonymsAFC
DescriptionExhibits high affinity for S-farnesylcysteine methyl transferase (Km = 20 µM), inhibiting the C-terminal methylation of protein in cell-free extracts and in whole cells. Known to block the fMLP-induced release of superoxides in human neutrophils (IC50 = 15 µM). Also inhibits carboxyl methylation of p21 platelet rap1 and the γ-subunit of transducin.
FormClear oil
Intert gas (Yes/No) Packaged under inert gas
CAS number135304-07-3
Chemical formulaC₂₀H₃₃NO₃S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesMolony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.