110115 N-Acetyl-S-geranylgeranyl-L-cysteine

110115
  
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      Replacement Information
      Description
      OverviewInhibitor of methylation of geranylgeranylated proteins that exhibits higher affinity (Km = 7 µM) than AFC (Cat. No. 110110) for carboxyl methyltransferase. A potent inhibitor of β2-integrin-induced actin polymerization (IC50 = 45 nM). An effective inhibitor of fMLP-induced superoxide generation (IC50 = 4 µM).
      Catalogue Number110115
      Brand Family Calbiochem®
      SynonymsAGGC
      References
      ReferencesRosado, J.A., and Sage, S.O. 2000. Biochem. J. 347, 183. Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Scheer, A., and Gierschik, P. 1995. Biochemistry 34, 4952. Philips, M.R., et al. 1993. Science 259, 977. Volker, C., et al. 1991. FEBS Lett. 295, 189.
      Product Information
      FormClear yellow viscous oil
      Hill FormulaC₂₅H₄₁NO₃S
      Chemical formulaC₂₅H₄₁NO₃S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetβ2-integrin-induced actin polymerization
      Primary Target IC<sub>50</sub>45 nM
      Secondary targetKnown to block the fMLP-induced release of superoxides in human neutrophils (IC₅₀ = 4 µM)
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      N-Acetyl-S-geranylgeranyl-L-cysteine Certificates of Analysis

      TitleLot Number
      110115

      References

      Přehled odkazů
      Rosado, J.A., and Sage, S.O. 2000. Biochem. J. 347, 183. Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Scheer, A., and Gierschik, P. 1995. Biochemistry 34, 4952. Philips, M.R., et al. 1993. Science 259, 977. Volker, C., et al. 1991. FEBS Lett. 295, 189.