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100066 NF-κB Activation Inhibitor V, 5HPP-33

100066
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
105624-86-0C₂₀H₂₁NO₃
Description
Overview

This product has been discontinued.





A cell-permeable N-phenylpthalimide compound that exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. Shown to exhibit potent inhibitory activity against IL-1-induced NF-κB translocation in HeLa cells (IC50 = 530 nM) and paclitaxel-like antimicrotubule activity. Effectively suppresses the proliferation of various cancer cells, including several Paclitaxel-resistant lines.
Catalogue Number100066
Brand Family Calbiochem®
Synonyms5-Hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione, 5HPP-33
References
Referencesde-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.
Product Information
CAS number105624-86-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₂₁NO₃
Chemical formulaC₂₀H₂₁NO₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetIL-1-induced NF-κB translocation
Primary Target IC<sub>50</sub>530 nM inhibiting IL-1-induced NF-κB translocation in HeLa cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

NF-κB Activation Inhibitor V, 5HPP-33 Certificates of Analysis

TitleLot Number
100066

References

Přehled odkazů
de-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms5-Hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione, 5HPP-33
DescriptionA cell-permeable N-phenylpthalimide compound that exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. Shown to exhibit potent inhibitory activity against IL-1-induced NF-κB translocation in HeLa cells (IC50 = 530 nM) and paclitaxel-like antimicrotubule activity. Effectively suppresses the proliferation of various cancer cells, including several Paclitaxel-resistant lines.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number105624-86-0
Chemical formulaC₂₀H₂₁NO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
Referencesde-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.