Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

504819 Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-5 - Calbiochem

504819
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1427782-89-5C₂₅H₂₀N₄O₂S₂
Description
OverviewA cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 (Cat. No. 681671) in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5 nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50 nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 (Cat. No. 681669) in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5 µM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice.
Catalogue Number504819
Brand Family Calbiochem®
SynonymsIWPL6, Wnt Pathway Inhibitor XIX
References
ReferencesWang, X., et al. 2013. J. Med. Chem. 56, 2700.
Product Information
CAS number1427782-89-5
FormOff-white solid
Hill FormulaC₂₅H₂₀N₄O₂S₂
Chemical formulaC₂₅H₂₀N₄O₂S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPorcupine
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
504819 0

Documentation

Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Wang, X., et al. 2013. J. Med. Chem. 56, 2700.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-September-2020 JSW
SynonymsIWPL6, Wnt Pathway Inhibitor XIX
DescriptionA cell-permeable, benzothiazole-to-5-phenylpyridin substituted IWP-2 (Cat. No. 681671) derivative that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5 vs. 30 nM) and 100-times more potent in blocking Wnt signaling-mediated branching morphogenesis in cultured murine embryonic kidneys (complete blockage with 50 nM IWP-L6 or 5 µM IWP-2). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 (Cat. No. 681669) in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5 µM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice (t1/2 = 2 and 190 min, respectively, in murine or rat plasma).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1427782-89-5
Chemical formulaC₂₅H₂₀N₄O₂S₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWang, X., et al. 2013. J. Med. Chem. 56, 2700.