324517 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

324517
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      Přehled

      Replacement Information

      Tabulka spec. kláve

      Empirical FormulaCAS #
      C₁₈H₁₂Cl₂N₄O₄S 315706-13-9

      Ceny a dostupnost

      Katalogové číslo DostupnostBalení ks/bal. Cena Množství
      324517-10MG
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          Plastová ampulka 10 mg
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          Vyžádat nacenění
          Description
          OverviewA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).
          Catalogue Number324517
          Brand Family Calbiochem®
          Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
          References
          ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
          Product Information
          CAS number315706-13-9
          FormYellow solid
          Hill FormulaC₁₈H₁₂Cl₂N₄O₄S
          Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationeIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
          Biological Information
          Purity≥98% by HPLC (sum of two isomers)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36-45

          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          324517

          References

          Přehled odkazů
          Moerke, N. J., et al. 2007. Cell 128, 257.

          Citations

          Název
        • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
        • Hoeffer et al. 2011. PNAS
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-December-2013 JSW
          Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
          DescriptionA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number315706-13-9
          Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC (sum of two isomers)
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
          Citation
        • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
        • Hoeffer et al. 2011. PNAS