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05-206 Anti-Laminin B2 Antibody, clone A5

50 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MIP, IHCRPurifiedMonoclonal Antibody
Catalogue Number05-206
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-Laminin B2 Antibody, clone A5
Product Information
Presentation0.1M Tris-glycine, pH 7.0
Quality LevelMQ100
ApplicationAnti-Laminin B2 Antibody, clone A5 is an antibody against Laminin B2 for use in IP, IH.
Key Applications
  • Immunoprecipitation
  • Immunohistochemistry
Application NotesNot recommended for WB.
Biological Information
ImmunogenMurine EHS laminin
Cloneclone A5
SpecificityB2 chain laminin; does not cross-react with other basement membrane components or fibronectin
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • LAMB2
  • S-laminin
  • LAMS
Purification MethodProtein G Chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 1798 amino acids; 195981 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.
Molecular Weight196 kDa
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated on unfixed, frozen monkey brain sections
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Global Trade Item Number
Catalogue Number GTIN
05-206 04053252473906


Anti-Laminin B2 Antibody, clone A5 SDS


Safety Data Sheet (SDS) 

Anti-Laminin B2 Antibody, clone A5 Certificates of Analysis

TitleLot Number
Anti-Laminin B2, clone A5 2475722
Anti-Laminin B2, clone A5 (rat monoclonal IgG) - 2424760 2424760
Anti-Laminin B2, clone A5 (rat monoclonal IgG) 3093126
Anti-Laminin B2, clone A5 (rat monoclonal IgG) 2982395
Anti-Laminin B2, clone A5 (rat monoclonal IgG) 3123634
Anti-Laminin B2, clone A5 (rat monoclonal IgG) - 1993895 1993895
Anti-Laminin B2, clone A5 - 11704 11704
Anti-Laminin B2, clone A5 - 2044812 2044812
Anti-Laminin B2, clone A5 - 2155404 2155404
Anti-Laminin B2, clone A5 - 2289135 2289135


Reference overviewApplicationPub Med ID
The pre- and post-somatic segments of the human type I spiral ganglion neurons--structural and functional considerations related to cochlear implantation.
Liu, W; Edin, F; Atturo, F; Rieger, G; Löwenheim, H; Senn, P; Blumer, M; Schrott-Fischer, A; Rask-Andersen, H; Glueckert, R
Neuroscience  284  470-82  2015

Show Abstract
Immunohistochemistry25316409 25316409
Macromolecular organization and fine structure of the human basilar membrane - RELEVANCE for cochlear implantation.
Liu, W; Atturo, F; Aldaya, R; Santi, P; Cureoglu, S; Obwegeser, S; Glueckert, R; Pfaller, K; Schrott-Fischer, A; Rask-Andersen, H
Cell and tissue research  360  245-62  2015

Show Abstract
25663274 25663274
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.
Cosgrove, BD; Gilbert, PM; Porpiglia, E; Mourkioti, F; Lee, SP; Corbel, SY; Llewellyn, ME; Delp, SL; Blau, HM
Nature medicine  20  255-64  2014

Show Abstract
24531378 24531378
Immunohistochemical distribution of basement membrane proteins in the human inner ear from older subjects.
Akira Ishiyama,Sarah E Mowry,Ivan A Lopez,Gail Ishiyama
Hearing research  254  2009

Show Abstract Full Text Article
19348877 19348877
Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Xunwei Wu,Shaohua Li,Anna Chrostek-Grashoff,Aleksandra Czuchra,Hannelore Meyer,Peter D Yurchenco,Cord Brakebusch
Developmental dynamics : an official publication of the American Association of Anatomists  236  2007

Show Abstract
17849438 17849438
Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo.
Brockbank, EC; Bridges, J; Marshall, CJ; Sahai, E
British journal of cancer  92  102-12  2005

Show Abstract
15597106 15597106
Contributions of the LG modules and furin processing to laminin-2 functions
Smirnov, S. P., et al
J Biol Chem, 277:18928-37 (2002)  2002

Immunocytochemistry11886875 11886875
Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies
Ljubimov, A. V., et al
Int J Cancer, 50:562-6 (1992)  1992

Immunoprecipitation, Immunohistochemistry (Tissue)1371500 1371500
Optimization of immunohistochemical techniques to detect extracellular matrix proteins in fixed skin specimens.
Folkvord, J M, et al.
J. Histochem. Cytochem., 37: 105-13 (1989)  1989

Show Abstract
Immunohistochemistry (Paraffin)2461979 2461979
Basement membrane components produced by a mouse ascites teratocarcinoma TB24. Analysis with monoclonal and polyclonal antibodies.
Ljubimov, A V, et al.
Exp. Cell Res., 165: 530-40 (1986)  1986

Show Abstract
3522258 3522258

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Life Science Research > Antibodies and Assays > Primary Antibodies