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MAB1914P Anti-Laminin gamma 1 Antibody, clone A5

100 µL  
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Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MIH(P)RPurifiedMonoclonal Antibody
Catalogue NumberMAB1914P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Laminin gamma 1 Antibody, clone A5
Alternate Names
  • LAMC1
Background InformationLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.
Product Information
  • Tubular carcinoma of the colon and fibroneuroma
PresentationPurified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Quality LevelMQ100
ApplicationDetect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenBasement membrane protein preparation from mouse EHS tumor.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • LAMC1
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (EHS laminin), laminin-2 (merosin), laminin-3 (S-laminin), laminin-4 (S-merosin), laminin-6 (K-laminin) and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
TISSUE SPECIFICITY: Found in the basement membranes (major component).
DOMAIN: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
DOMAIN: Domains VI and IV are globular.
SIMILARITY: Contains 11 laminin EGF-like domains.
SIMILARITY: Contains 1 laminin IV type A domain.
SIMILARITY: Contains 1 laminin N-terminal domain.
Molecular Weight177 kDa
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Global Trade Item Number
Catalogue Number GTIN
MAB1914P 04053252503191


Anti-Laminin gamma 1 Antibody, clone A5 SDS


Safety Data Sheet (SDS) 

Anti-Laminin gamma 1 Antibody, clone A5 Certificates of Analysis

TitleLot Number
Anti-Laminin gamma 1, clone A5 - 2386528 2386528
Anti-Laminin gamma 1, clone A5 - 2011984 2011984
Anti-Laminin gamma 1, clone A5 - 2058381 2058381
Anti-Laminin gamma 1, clone A5 - 2153086 2153086
Anti-Laminin gamma 1, clone A5 - 2228133 2228133
Anti-Laminin gamma 1, clone A5 - 2300034 2300034
Anti-Laminin gamma 1, clone A5 - 2565746 2565746
Anti-Laminin gamma 1, clone A5 - 3224576 3224576
Anti-Laminin gamma 1, clone A5 - 3439207 3439207
Anti-Laminin gamma 1, clone A5 - 3660406 3660406


Reference overviewPub Med ID
Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop
Daniel Öhlund 1 , Oskar Franklin, Erik Lundberg, Christina Lundin, Malin Sund
BMC Cancer  13  154  2013

Show Abstract
23530721 23530721
Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.
Wiradjaja, F; Cottle, DL; Jones, L; Smyth, I
Disease models & mechanisms  6  1426-33  2013

Show Abstract
24046351 24046351

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Product Families


Life Science Research > Antibodies and Assays > Primary Antibodies