TGFBMAG-64K-03
MILLIPLEX® Multi-Species TGFß Panel
Premixed Multi-Species TGFß 3-Plex Panel
Synonym(s):
3 Plex TGFß Assay, TGFß Magnetic Bead Kit
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
Product Name
MILLIPLEX® Multi-Species TGFß Panel, Premixed Multi-Species TGFß 3-Plex Panel
manufacturer/tradename
Milliplex®
Quality Level
species reactivity
horse, human, guinea pig, nonhuman primates, pig (mini), hamster, mouse, rat
packaging
1 ea of
assay range
accuracy: 62-128%
sensitivity: 8-12 pg/mL
standard curve range: 9.8-2,500 pg/mL
technique(s)
multiplexing: suitable
input
cell culture supernatant(s)
compatibility
configured for Premixed
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 3 analytes in multi-species serum, plasma, and cell culture supernatants.
Analytes included: TGF-β1, TGF-β2, TGF-β3 NOTE: This assay requires a sample acidification treatment using the provided reagents and protocol.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: TGF-β1, TGF-β2, TGF-β3 NOTE: This assay requires a sample acidification treatment using the provided reagents and protocol.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
Triple Isoform Detection: Simultaneously quantifies TGFβ1, TGFβ2, and TGFβ3, providing a complete profile of TGFβ signaling.
Wide Species Reactivity: Verified for human, mouse, rat, pig, hamster, guinea pigs, and non-human primates.
Includes Sample Acidification Protocol: To measure active TGFβ, samples must undergo acid treatment. This step is critical for converting latent TGFβ into its active form, ensuring accurate quantification.
Wide Dynamic Range: Standard curve spans 9.8–10,000 pg/mL.
Versatile Applications: Ideal for basic research, translational studies, and therapeutic development.
Wide Species Reactivity: Verified for human, mouse, rat, pig, hamster, guinea pigs, and non-human primates.
Includes Sample Acidification Protocol: To measure active TGFβ, samples must undergo acid treatment. This step is critical for converting latent TGFβ into its active form, ensuring accurate quantification.
Wide Dynamic Range: Standard curve spans 9.8–10,000 pg/mL.
Versatile Applications: Ideal for basic research, translational studies, and therapeutic development.
General description
The transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - Skin Sens. 1
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lingwen Ying et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 4661-4670 (2021-12-09)
We aimed to explore the immunological characteristics and cytokine profile of the initial stage of type 1 diabetes. In total, 123 age- and sex-matched subjects with newly diagnosed classic type 1 diabetes mellitus (T1ADM), fulminant type 1 diabetes mellitus (FT1DM)
Lerin R Luckett-Chastain et al.
Experimental dermatology, 26(8), 697-704 (2016-11-29)
It been shown that IL-6 modulates TGF-β1 expression in fibroblasts, however, what role IL-6 plays concerning TGF-βR expression and function in skin is unknown. Therefore, the aim of this study was to investigate the mechanism by which IL-6 might modulates
Samantha M Logan et al.
PeerJ, 7, e8116-e8116 (2019-11-26)
To conserve energy in times of limited resource availability, particularly during cold winters, hibernators suppress even the most basic of physiologic processes. Breathing rates decrease from 40 breaths/minute to less than 1 breath/min as they decrease body temperature from 37
Julien Fourcade et al.
JCI insight, 3(14) (2018-07-27)
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expression and decreased expression
Beate Obermüller et al.
Nutrients, 12(7) (2020-07-12)
Malignant diseases can cause tumor-associated cachexia (TAC). Supplementation with prebiotic non-digestible carbohydrates exerts positive metabolic effects in experimental oncologic diseases. The aim of this project was to assess the effect of prebiotic supplementation with OMNi-LOGiC® FIBRE on intestinal microbiome, bacterial
Global Trade Item Number
| SKU | GTIN |
|---|---|
| TGFBMAG-64K-03 | 04055977289183 |
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