H4381
6-Hydroxydopamine hydrochloride
≥97% (titration), powder, neurotoxin
Sinónimos:
2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Cambiar Vistas
Acerca de este artículo
Fórmula lineal:
(HO)3C6H2CH2CH2NH2 · HCl
Número CAS:
Peso molecular:
205.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
248-837-2
MDL number:
Beilstein/REAXYS Number:
4274007
Assay:
≥97% (titration)
Form:
powder
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleNombre del producto
6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
Quality Segment
assay
≥97% (titration)
form
powder
color
off-white to brown
mp
232-233 °C (dec.) (lit.)
solubility
H2O: >50 mg/mL, clear, yellow to brown
storage temp.
room temp
SMILES string
Cl.NCCc1cc(O)c(O)cc1O
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI key
QLMRJHFAGVFUAC-UHFFFAOYSA-N
General description
6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Application
6-hydroxydopamine hydrochloride has been used:
- to induce Parkinson′s disease (PD) in rats
- to analyse cytotoxic effect of 6-OHDA on PC12 cell line
- to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
Biochem/physiol Actions
Neurotoxin that destroys catecholaminergic terminals.
Preparation Note
Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.
Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.