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531620 APT1 Inhibitor II, Cpd21 - CAS 899713-86-1 - Calbiochem

531620
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
899713-86-1C₁₈H₁₇ClF₃N₃O₃

Products

Número de referenciaEmbalaje Cant./Env.
5316200001 Frasco de vidrio 10 mg
Description
OverviewA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531620
Brand Family Calbiochem®
SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
References
ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
Product Information
CAS number899713-86-1
FormWhite solid
Hill FormulaC₁₈H₁₇ClF₃N₃O₃
Chemical formulaC₁₈H₁₇ClF₃N₃O₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetAPT1
Primary Target IC<sub>50</sub>840 nM, Ki
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
5316200001 04055977259971

Documentation

APT1 Inhibitor II, Cpd21 - CAS 899713-86-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Adibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.

Folleto

Cargo
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Licencias necesarias e Información técnica

Cargo
White Paper: Further considerations of antibody validation and usage.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-December-2014
SynonymsLYPLA1 Inhibitor, Lysophospholipase Inhibitor
DescriptionA cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number899713-86-1
Chemical formulaC₁₈H₁₇ClF₃N₃O₃
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.