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205531 CA-074 Me - Calbiochem

205531
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₉H₃₁N₃O₆

Products

Número de referenciaEmbalaje Cant./Env.
205531-1MG Ampolla de plást. 1 mg
Description
OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Catalogue Number205531
Brand Family Calbiochem®
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
References
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Product Information
CAS number147859-80-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₁N₃O₆
Chemical formulaC₁₉H₃₁N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

CA-074 Me - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

CA-074 Me - Calbiochem Certificados de análisis

CargoNúmero de lote
205531

Referencias bibliográficas

Visión general referencias
Sever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

Citas

Título
IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
FormWhite solid
CAS number147859-80-1
Chemical formulaC₁₉H₃₁N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.