219672 Sigma-AldrichCFTR Inhibitor III, OXO-172 - Calbiochem
The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<CFTR Inhibitor III, OXO-172 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
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Descripción
Replacement Information |
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Tabla espec. clave
Empirical Formula |
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C₁₈H₁₀F₃NO₄S |
Products
Número de referencia | Embalaje | Cant./Env. | |
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219672-10MG | Ampolla de plást. | 10 mg |
Description | |
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Overview | A cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM). |
Catalogue Number | 219672 |
Brand Family | Calbiochem® |
Synonyms | 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172 |
References | |
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References | Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187. |
Product Information | |
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Form | Off-white solid |
Hill Formula | C₁₈H₁₀F₃NO₄S |
Chemical formula | C₁₈H₁₀F₃NO₄S |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Purity | ≥95% by HPLC and NMR |
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Dimensions |
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Materials Information |
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Safety Information according to GHS |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Documentation
CFTR Inhibitor III, OXO-172 - Calbiochem Ficha datos de seguridad (MSDS)
Título |
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CFTR Inhibitor III, OXO-172 - Calbiochem Certificados de análisis
Cargo | Número de lote |
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219672 |
Referencias bibliográficas
Visión general referencias |
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Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187. |