239777 Sigma-AldrichCyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem
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Primary Target:
Catalyzes the cis-trans-isomerization of X-Pro peptide bonds
Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: Peptidylproline cis-trans-Isomerase
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Descripción
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Tabla espec. clave
CAS # |
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95076-93-0 |
Products
Número de referencia | Embalaje | Cant./Env. | |
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239777-100UG | Tambor de alum | 100 μg |
Description | |
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Overview | Recombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity. |
Catalogue Number | 239777 |
Brand Family | Calbiochem® |
Synonyms | Peptidylproline cis-trans-Isomerase |
Product Information | |
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CAS number | 95076-93-0 |
ATP Competitive | N |
EC number | 5.2.1.8 |
Form | Liquid |
Formulation | In 20 mM Tris-HCl, pH 7.8. |
Reversible | N |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | Catalyzes the cis-trans-isomerization of X-Pro peptide bonds |
Purity | ≥90% by SDS-PAGE |
Concentration Label | Please refer to vial label for lot-specific concentration |
Physicochemical Information | |
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Cell permeable | N |
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Safety Information according to GHS |
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Safety Information | |
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S Phrase | S: 24/25-36 Avoid contact with skin and eyes. Wear suitable protective clothing. |
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Supplemental Information |
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Specifications |
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Documentation
Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem Certificados de análisis
Cargo | Número de lote |
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239777 |
Referencias bibliográficas
Visión general referencias |
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Fruman, D.A., et al. 1994. FASEB J. 8, 391. Galat, A. 1993. Eur. J. Biochem. 216, 689. Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334. Luban, L., et al. 1993. Cell 73, 1067. Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474. Kofron, J.L., et al. 1991. Biochemistry 30, 6127. |