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239777 Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Peptidylproline cis-trans-Isomerase

Primary Target: Catalyzes the cis-trans-isomerization of X-Pro peptide bonds
239777
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Descripción

Replacement Information

Tabla espec. clave

CAS #
95076-93-0

Products

Número de referenciaEmbalaje Cant./Env.
239777-100UG Tambor de alum 100 μg
Description
OverviewRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
Catalogue Number239777
Brand Family Calbiochem®
SynonymsPeptidylproline cis-trans-Isomerase
References
ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
Galat, A. 1993. Eur. J. Biochem. 216, 689.
Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
Luban, L., et al. 1993. Cell 73, 1067.
Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
Product Information
CAS number95076-93-0
ATP CompetitiveN
EC number5.2.1.8
FormLiquid
FormulationIn 20 mM Tris-HCl, pH 7.8.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCatalyzes the cis-trans-isomerization of X-Pro peptide bonds
Purity≥90% by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 24/25-36

Avoid contact with skin and eyes.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
239777

Referencias bibliográficas

Visión general referencias
Fruman, D.A., et al. 1994. FASEB J. 8, 391.
Galat, A. 1993. Eur. J. Biochem. 216, 689.
Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
Luban, L., et al. 1993. Cell 73, 1067.
Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-December-2008 RFH
SynonymsPeptidylproline cis-trans-Isomerase
DescriptionRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomeration of X-Pro-peptide bonds. Binds to proteins and acts as chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin is characterized by its binding to the immunosuppressant cyclosporin A. This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
FormLiquid
FormulationIn 20 mM Tris-HCl, pH 7.8.
Concentration Label Please refer to vial label for lot-specific concentration
CAS number95076-93-0
EC number5.2.1.8
Purity≥90% by SDS-PAGE
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
Toxicity Standard Handling
ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
Galat, A. 1993. Eur. J. Biochem. 216, 689.
Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
Luban, L., et al. 1993. Cell 73, 1067.
Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
Kofron, J.L., et al. 1991. Biochemistry 30, 6127.